finasteride prescription Development of PanINs and PDACs can be accelerated by introducing inactivating mutations in the tumor suppressor genes Cdkn2a, Trp53, or Dpc4 Smad4, all of which occur frequently in human lesions as they progress to invasive PDAC Jones et al, 2008; Morris et al, 2010; BiankinWaddell et al, 2012 and by enhancing critical signaling pathways such as those of EGFR, Raf Mek Erk, PI3K Pdk1 Akt, and Ral Lim et al, 2005; Feldmann et al, 2010; Collisson et al, 2012; Eser et al, 2013