Genes whose expression increased in CD47 KO brain cells were significantly enriched in pathways for T cell receptor signaling, axon guidance, proteoglycans in cancer, TNF signaling, and NF ОєB signaling Figure 5A; genes whose expression decreased in CD47 KO brain cells were enriched in cancer associated pathways including Wnt, Hippo, and Rap1 signaling, as well as cardiomyopathy Figure 5B cialis for daily use